The center develops and uses the GAMA platform, initially created within the center in 2007, to design models capable of simulating complex systems involving numerous actors and interactions.
This work is mobilized in several areas:

- Agriculture and climate: developing scenarios to reduce greenhouse gas emissions and support the agroecological transition in the Mekong Delta.
- Water and natural hazard management: modeling floods, saltwater intrusion and landslides to improve warning systems and decision support.
- Public health: design of epidemiological simulation models and development of tools such as GeoTB, a platform for visualizing and analyzing tuberculosis trends based on environmental, social and health data.
- Fisheries, ecological resources: bio-economic modeling of fisheries, effects of spatial heterogeneity in population dynamics.

This research is also aimed at improving the ability of models to operate on large scales (watersheds, provinces, countries) and at integrating different scientific approaches into hybrid models.

Another key challenge is to develop collaborative modeling methods that bring together researchers, decision-makers and local stakeholders in the construction and use of models.

The center relies on the ACROSS International Joint Laboratory, based at Thuy Loi University (Hanoi), which develops modeling tools for the participative management of irrigation systems in Vietnam, particularly in the Red River and Mekong deltas.

Several initiatives reinforce this participatory dimension:

- SUCCESS (Erasmus+): creation of “third places” to encourage exchanges between researchers and civil society on urban issues.
- SIMPLE: using immersive virtual worlds to raise awareness of environmental issues in Southeast Asia among young people (aged 12-18).
- Digital Twin Platform: development of participative digital twins to study mobility, air quality and health in urban environments, with an initial case study in Hanoi.

These initiatives aim to strengthen the dialogue between science and society and develop new forms of interaction with scientific simulations.